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Texans Seek Redemption vs. Colts in Must-Win Showdown
27 Sep
Summary
- Texans and Colts both aim for their first win at 0-2.
- Houston has won the last five meetings against Indianapolis.
- Key Texans players, including WR Nico Collins, are out.

The Houston Texans and Indianapolis Colts are set for a pivotal AFC South clash on Sunday, September 27, 2026, as both teams desperately seek their first victory of the season. Currently holding 0-2 records, a loss would push either team into a daunting 0-3 hole. Historically, the Texans have held the upper hand, having won the last five consecutive games against the Colts, a streak they aim to extend for a significant confidence boost.
Kickoff is scheduled for 12:00 p.m. CT at Lucas Oil Stadium in Indianapolis. The game will be broadcast on NFL Network and CBS, with local coverage on KHOU-11 and out-of-market streaming via NFL+. The Texans face significant injury concerns, with wide receiver Nico Collins and offensive guard Ed Ingram already ruled out for their second consecutive game. Veteran tackle Trent Brown is questionable with knee and wrist issues, potentially impacting Houston's offensive line further.
The Colts also have their share of injury woes. Wide receiver Alec Pierce has been placed on injured reserve with a heel injury, sidelining him for the next four games. Cornerback Charvarius Ward is questionable with a groin issue but is expected to play. Despite these absences, the Texans are favored by 1.5 points, with a moneyline of -124, indicating a slight edge on the road.