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Stafford's Passing Frenzy Leads Rams to Decisive Win Over 49ers
10 Nov
Summary
- Stafford throws 4 TDs, most in 3-game span for Rams
- Rams avenge earlier OT loss to 49ers, remain tied for 1st in NFC West
- 49ers missing key defensive players Bosa and Warner, lose rookie Williams for season

On November 6, 2022, the Los Angeles Rams defeated the San Francisco 49ers 42-26 in a crucial NFC West matchup. Rams quarterback Matthew Stafford was the driving force behind the victory, throwing 4 touchdown passes to give him the most in a 3-game span in franchise history.
The win allowed the Rams (7-2) to avenge their earlier overtime loss to the 49ers (6-4) in Week 5 and remain tied for first place in the division with the Seattle Seahawks. Stafford has been on a tear, leading the NFL with 25 touchdown passes and throwing 20 TDs without an interception in the past 6 games.
The 49ers were hampered by injuries to their top defensive players, with Nick Bosa, Fred Warner, and rookie Mykel Williams all out for the season. Despite moving the ball well, San Francisco struggled to contain Stafford and the Rams' passing attack, which scored touchdowns on their first 3 possessions to take a 21-0 lead.
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Rams running back Kyren Williams also contributed 2 touchdown runs in the victory. The 49ers' Mac Jones threw for 319 yards and 3 touchdowns, but it wasn't enough to overcome the Rams' offensive onslaught.




