Can the Virginia Tech Hokies upset the No. 17 Louisville Cardinals?

Yes, the Hokies will look to use their home-field advantage at Lane Stadium to keep the game close and potentially pull off the upset against the ranked Cardinals.

How have the Louisville Cardinals performed against the spread this season?

The Cardinals have struggled to meet expectations against the spread, going just 2-5 ATS so far this season.

Home / Sports / Ranked Cardinals Seek Redemption Against Underdog Hokies in Thrilling Matchup

Ranked Cardinals Seek Redemption Against Underdog Hokies in Thrilling Matchup

Q: What was the Cardinals' standout win of the season?

The Cardinals' standout win of the season was a 24-21 road triumph over the No. 9 Miami Hurricanes.

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Summary

No. 17 Louisville Cardinals face off against Virginia Tech Hokies in ACC clash
Cardinals looking to bounce back after close loss to Virginia Cavaliers
Hokies seeking to upset ranked opponent and snap 2-game losing streak

Ranked Cardinals Seek Redemption Against Underdog Hokies in Thrilling Matchup

On November 1, 2025, the No. 17 Louisville Cardinals (6-1, 3-1 ACC) will travel to Blacksburg, Virginia, to take on the Virginia Tech Hokies (3-5, 2-2) in a crucial ACC matchup. The Cardinals are looking to bounce back after suffering their lone loss of the season in overtime against the Virginia Cavaliers last month. Meanwhile, the Hokies are seeking to upset the ranked opponent and snap their 2-game losing streak.

The Cardinals are coming off a 38-24 victory over the Boston College Eagles last weekend, though they failed to cover the 26-point spread. Prior to that, Louisville's standout win of the season was a 24-21 road triumph over the No. 9 Miami Hurricanes. The Hokies, on the other hand, recently snapped their own 2-game skid with a 42-34 overtime victory against the Cal Bears at home.