Who won the Rams vs. 49ers game on Thursday Night Football?

The Los Angeles Rams defeated the San Francisco 49ers in their Week 5 matchup.

How did Rams QB Matthew Stafford perform against the 49ers?

Stafford had an impressive game, throwing for 375 yards and 3 touchdowns on 29-of-41 passing.

What was the 49ers' record before their game against the Rams?

The 49ers entered the Week 5 matchup with a 3-1 record, the same as the Rams.

Home / Sports / Rams Edge 49ers in Crucial NFC West Clash

Rams Edge 49ers in Crucial NFC West Clash

2 Oct

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Summary

Rams and 49ers both 3-1 before Week 5 matchup
Rams bounce back from Week 3 collapse, 49ers lose at home
Stafford throws for 375 yards, 3 TDs for Rams

Rams Edge 49ers in Crucial NFC West Clash

On Thursday, October 3rd, 2025, the Los Angeles Rams and San Francisco 49ers squared off in a crucial NFC West matchup. Both teams entered the game with 3-1 records, setting the stage for an important early-season divisional clash.

The Rams were looking to bounce back after a brutal collapse against the Eagles in Week 3, while the 49ers were aiming to rebound from a home loss to the Jaguars in Week 4. Rams quarterback Matthew Stafford rose to the occasion, throwing for 375 yards and 3 touchdowns on 29-of-41 passing. His standout performance helped the Rams secure a hard-fought victory over their division rivals.

The 49ers, led by quarterback Brock Purdy, put up a valiant effort, but their comeback bid ultimately fell short. Purdy threw for 309 yards, 2 touchdowns, and 2 interceptions, also losing a fumble in the game.

With this win, the Rams have taken control of the NFC West standings, while the 49ers will look to regroup and mount a challenge in the coming weeks.

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