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Injured Kyler Murray Ruled Out, Veteran Brissett to Start for Cardinals
12 Oct
Summary
- Arizona Cardinals QB Kyler Murray will miss Sunday's game against the Colts
- Murray has an injured foot and did not practice earlier this week
- Longtime QB Jacoby Brissett will start in Murray's place
On October 12, 2025, the Arizona Cardinals announced that star quarterback Kyler Murray will not play in their upcoming game against the Indianapolis Colts. Murray has been dealing with a foot injury and did not practice earlier this week.
The 25-year-old Murray, who has not missed a game since 2023, was injured in the second half of the Cardinals' 22-21 loss to the Tennessee Titans last week. He missed two plays late in the third quarter to receive treatment but was able to finish the game, though he was visibly limping at times.
With Murray sidelined, the Cardinals will turn to veteran quarterback Jacoby Brissett to lead the offense. The 32-year-old Brissett has started 53 of his 89 career games over the past 10 seasons, including stints with the Patriots, Colts, Dolphins, Browns, and Commanders.
The Cardinals (2-3) are hoping Brissett can help them end their three-game losing skid and get back on track against the Colts (2-3) this Sunday.
