Fantasy Football Injury Tracker: Key Players to Watch Ahead of Week 1

With the 2025 NFL regular season fast approaching, fantasy football managers are closely monitoring the latest injury news around the league. As of August 21st, 2025, several high-profile players are dealing with various ailments that could impact their availability and production for Week 1.

Quarterbacks Lamar Jackson, Aaron Rodgers, and Matthew Stafford have all been in the spotlight for their injury concerns. Jackson was forced to leave practice after a teammate stepped on his foot, though the Ravens have downplayed the issue. Rodgers underwent a procedure to repair torn ligaments in his non-throwing thumb and is expected to be ready for Week 1. Stafford's back injury has been a major storyline, and his status remains uncertain as the Rams take a cautious approach.

In the backfield, rookie Achane of the Dolphins and veteran Mixon of the Texans have also been sidelined with injuries. Achane's injury is being handled in a "preventative" manner, while Mixon's status for Week 1 is unclear. These situations have created opportunities for other running backs on those teams to potentially emerge.

The wide receiver position has also been hit hard by injuries. Chris Godwin of the Buccaneers is unlikely to play until October, opening the door for rookie Emeka Egbuka. Packers' Christian Reed is out of a walking boot but still not practicing, while Khalil Shakir of the Bills is recovering from a high-ankle sprain. These receiver injuries could significantly impact the fantasy value of their respective teams' passing attacks.

As the preseason winds down, fantasy managers will need to stay vigilant and adjust their draft strategies accordingly to navigate these injury-riddled situations.