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Cowboys and Eagles Clash in High-Stakes NFL Kickoff Game
27 Aug
Summary
- Eagles RB Saquon Barkley had 233 rushing yards vs Cowboys in 2024
- Cowboys WR George Pickens set to make debut
- DFS expert McClure shares top picks for NFL Kickoff game

The 2025 NFL season will kick off on September 4 with a highly anticipated matchup between the Dallas Cowboys and the Philadelphia Eagles. The game, which will be played at Lincoln Financial Field, is scheduled for an 8:20 p.m. ET start.
The Eagles enter the game as 7-point favorites, with the over/under set at 46.5 points. This single-game slate is expected to draw significant interest from NFL DFS players, who will be looking to capitalize on potential sleepers and build lineup variance.
One player who could be a key factor in the game is Eagles running back Saquon Barkley. The former Penn State standout had a stellar 2024 season, rushing for 2,005 yards and 13 touchdowns. Barkley also had success against the Cowboys, racking up 233 rushing yards in two games. With the potential absence of Cowboys linebacker Micah Parsons, Barkley could be poised for another big performance.
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On the other side, the Cowboys will be debuting wide receiver George Pickens, who could be a valuable addition to their offense. Pickens will look to make an immediate impact, potentially challenging the likes of DeVonta Smith, A.J. Brown, and CeeDee Lamb for targets.
As the game approaches, DFS expert Mike McClure has already identified his top picks for the NFL Kickoff Game. McClure, a legendary DFS player with over $2 million in career winnings, has a proven track record of success and will be sharing his insights with members at SportsLine.