Who are the top players to watch in the 2025 NFL Sao Paulo Game?

Patrick Mahomes, the Chiefs' star quarterback, and Justin Herbert, the Chargers' talented young QB, are two of the biggest names to watch in this matchup.

What makes the 2025 NFL Sao Paulo Game a must-see event?

The game features a loaded NFL DFS player pool, with stars like Travis Kelce, Ladd McConkey, and Xavier Worthy leading the way. It's an exciting season opener between two AFC West rivals.

How can fans build winning DFS lineups for the 2025 NFL Sao Paulo Game?

DFS expert Jimmie Kaylor has identified key sleepers and strategies to help build successful lineups, including targeting Mahomes and McConkey as top plays.

Home / Sports / Chiefs and Chargers Clash in Highly Anticipated 2025 NFL Sao Paulo Game

Chiefs and Chargers Clash in Highly Anticipated 2025 NFL Sao Paulo Game

5 Sep

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Summary

Chiefs and Chargers open 2025 NFL season in Sao Paulo, Brazil
Loaded NFL DFS player pool with stars like Mahomes, Kelce, Herbert
Kaylor's expert DFS picks highlight undervalued players like Ladd McConkey

Chiefs and Chargers Clash in Highly Anticipated 2025 NFL Sao Paulo Game

On Friday, September 5, 2025, the Kansas City Chiefs and Los Angeles Chargers will open their NFL seasons with a highly anticipated AFC West showdown in the 2025 NFL Sao Paulo Game. Kickoff is scheduled for 8 p.m. ET at Corinthians Arena in Sao Paulo, Brazil.

The game features a loaded NFL DFS player pool, with some of the biggest names in the sport leading the way. Kansas City quarterback Patrick Mahomes, tight end Travis Kelce, and rookie wide receiver Xavier Worthy will face off against Chargers quarterback Justin Herbert and second-year wideout Ladd McConkey. Building successful DFS lineups and stacks for this matchup will require finding the right mix of high-priced stars and undervalued sleepers.

SportsLine NFL DFS expert Jimmie Kaylor has identified several key players to target for the 2025 NFL Sao Paulo Game. Kaylor is recommending Mahomes as a top quarterback option, highlighting the 29-year-old's dominant career numbers against the Chargers. He's also high on McConkey, who emerged as the Chargers' top receiving threat as a rookie in 2024. Kaylor believes McConkey will see heavy volume and could provide excellent value in DFS contests.

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