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49ers Release WR, Sign New Talent in Roster Shakeup
5 Aug
Summary
- 49ers release WR Andy Isabella due to ankle injury
- Sign Equanimeous St. Brown to 1-year deal
- St. Brown has 63 receptions, 928 yards, 2 TDs in career

In a roster move on August 5th, 2025, the San Francisco 49ers have released wide receiver Andy Isabella and signed Equanimeous St. Brown to a one-year contract. The decision came after Isabella suffered an ankle injury during practice earlier this week.
St. Brown, a 28-year-old wide receiver, was originally drafted by the Green Bay Packers in 2018 and has since played for the Chicago Bears and New Orleans Saints. Over his 4-year NFL career, he has recorded 63 receptions for 928 yards and 2 touchdowns. Prior to the pros, St. Brown attended the University of Notre Dame, where he had 92 catches for 1,484 yards and 13 touchdowns.
The 49ers are hoping St. Brown can provide depth and playmaking ability to their receiving corps as they look to bounce back from a disappointing 2024 season. With the release of Isabella and addition of St. Brown, the team is shaking up their roster in search of the right mix of talent to support star quarterback Trey Lance.