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Injury Crisis: 21 49ers Absent Ahead of Crucial Chargers Prep
17 Aug
Summary
- Twenty-one 49ers players missed or exited practice Sunday.
- New absences include key offensive and defensive players.
- Roster battles intensify with Week 1 approaching rapidly.

As of August 17, 2026, the San Francisco 49ers are experiencing a widespread injury concern affecting 21 players. Sunday's practice saw five new absences and two players exiting due to injuries, exacerbating an already lengthy list that includes individuals still on the PUP list. The team is preparing for joint practices with the Los Angeles Chargers on Tuesday, a critical opportunity for players vying for starting positions and roster spots.
With the regular season opener against the Los Angeles Rams on September 10th just weeks away, the clock is ticking for injured players to recover. This mounting list of sidelined players also impacts those fighting to secure a place on the 53-man roster. The upcoming preseason game against the Chargers on Thursday evening at SoFi Stadium further highlights the urgent need for key players to return to health.