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College Football Week 4: Top Picks Revealed!
24 Sep
Summary
- SportsLine's model simulates every game 10,000 times.
- Colorado is 11-5-2 against the spread after a loss.
- USC has scored 35+ points in first four games.

The 2026 college football season is set to kick off its fourth week, marking the official start of conference play for numerous teams. SportsLine's advanced prediction model, renowned for its rigorous simulation of every game 10,000 times, has unveiled its expert picks for all FBS matchups.
This season, the model is demonstrating strong performance with a 22-19 record on its top-rated college football selections. It has also been enhanced for 2026 to better account for the impact of the transfer portal, providing more refined predictions.
Among the highlighted predictions is Colorado (+10) covering the spread against Baylor. The Buffaloes have shown remarkable resilience, boasting an 11-5-2 ATS record following a defeat since 2023, ranking them among the best in FBS for post-loss performance.
In another significant prediction, USC (+3) is favored to cover at home against Oregon. The Trojans' offense has been a scoring machine, achieving 35 or more points in each of their first four games this season for the third time in program history. Quarterback Jayden Maiava has a strong 11-1 home record with the team.