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Space Gut: Microgravity Linked to Protein Fermentation
31 Aug
Summary
- Astronauts show increased gut protein fermentation within weeks in space.
- Microgravity may slow food transit, leading to protein fermentation.
- Findings could guide interventions to improve astronaut gut health.

Constipation is a common ailment for astronauts, and new research suggests microgravity plays a significant role. Scientists have identified key biological markers that may explain this digestive disruption.
The study examined blood samples from 52 astronauts who spent at least two months on the International Space Station. Researchers observed that within weeks of arriving in space, astronauts' gut bacteria began fermenting protein more than usual.
This increased protein fermentation occurs when dietary fiber is depleted, causing gut bacteria to break down protein instead. Analysis of blood metabolites revealed these changes, offering insights into digestive function.
Researchers believe the lack of gravity slows food transit in the intestine, contributing to the observed protein fermentation. This could explain astronaut constipation and potentially lead to health issues like kidney damage and mood disturbances.
These findings are crucial for planning extended deep-space missions. The research suggests potential interventions, including increasing dietary fiber, supplementation with prebiotics, or treatments promoting gut motility. Such measures could mitigate negative health consequences by ensuring a healthy gut environment.