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Probiotic Strain Targets Urate, Offers Gout Relief Hope
22 Apr
Summary
- Probiotic L. plantarum FS4722 shows promise for urate regulation.
- Strain from pickled vegetables offers natural hyperuricemia support.
- FS4722 demonstrates drug-like control with better safety in mice.
A novel probiotic strain, Lactiplantibacillus plantarum FS4722, isolated from traditional Chinese pickled vegetables, is showing considerable potential for managing hyperuricemia. This strain, developed by SynbioTech, has demonstrated a multi-pronged approach to regulating uric acid levels in preclinical studies.
FS4722 works by targeting multiple pathways within the gut-liver-kidney axis. It is noted to limit the absorption of purines in the intestines, reduce uric acid production in the liver, and enhance its excretion through the gut and kidneys. The probiotic also helps rebalance the gut microbiome and its metabolites.
Preclinical trials in mice indicated that L. plantarum FS4722 can lower serum uric acid levels comparably to conventional drugs, but with a significantly better safety profile. Unlike some medications, FS4722 did not appear to impair kidney function or cause pathological tissue abnormalities.
The findings were published in the journal Microbiome and presented at the Asian Conference on Lactic Acid Bacteria, attracting international attention. Hyperuricemia, a condition linked to gout, diabetes, and kidney dysfunction, is a growing global health concern, with prevalence rates as high as 22% in Taiwanese men.
