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Fruit Fly Brain Mapped, Now Playing Video Games!
8 Sep
Summary
- A complete fruit fly brain map with 166,000 neurons was published.
- Online developers are using the data to teach simulated fly brains games.
- Future research aims to understand perception and repair neural pathways.

Researchers have successfully mapped every neural connection in the adult fruit fly's brain and central nervous system, a groundbreaking achievement published on September 3rd. This connectome, comprising over 166,000 neurons and 125 million synaptic connections, is the largest brain map by neuron count to date, serving as a critical resource for studying brain function in model organisms.
The creation of this intricate wiring diagram involved slicing the nervous system into microscopic sections, imaging them with electron microscopy, and employing AI for 3D reconstruction. Years were dedicated to verifying and annotating the data, aiming to unlock how nervous systems perceive the world and react to stimuli.
In the days following the publication, the scientific data has sparked creative online experiments. Developers are leveraging the connectome to train simulated fly brains to play video games such as Doom and Super Mario 64, with neural activity mapped to game controls. Other users have adapted the simulations for diverse applications, including responding to tones and reacting to animations, demonstrating the versatile potential of this neuroscience milestone.