Portugal's Cancer Breakthrough: Lithium-6 Nanocapsules

A novel approach to cancer treatment is being developed at the University of Aveiro in Portugal, utilizing carbon nanocapsules filled with lithium-6.

This CarboNCT project aims to enhance radiotherapy's effectiveness while significantly reducing damage to surrounding healthy tissues. The method involves introducing lithium-6 into cancer cells, which then triggers a highly localized nuclear reaction when exposed to neutrons, destroying the cells.

Traditionally, Neutron Capture Therapy (NCT) uses boron-10. However, lithium-6 is being explored for its potential to increase therapeutic efficiency and precision. The nanocapsules are multifunctional, designed for stable transport of isotopes and controlled delivery.

Initial results show promising biocompatibility with non-cancerous cells and effective accumulation in tumor cells. The natural fluorescence of these nanoparticles could also enable real-time monitoring of their presence within cells.

Developed in collaboration with the University of Coimbra and the University of Pavia, this research could lead to a new generation of neutron therapy drugs if further clinical trials prove successful.

This innovation comes as cancer remains a leading global cause of death, with Portugal expecting a significant increase in new cases by 2040.