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Body's Own Protein Fights Superbugs
24 Feb
Summary
- Human protein blocks bacterial biofilm formation.
- Biofilms make bacteria 1,000 times more resistant to antibiotics.
- Discovery offers a new strategy beyond traditional antibiotics.
Scientists at the Indian Institute of Technology Jodhpur have identified a significant breakthrough in combating antibiotic resistance. Their research revealed that a naturally present human protein, beta-2-microglobulin (β2m), can inhibit the formation of bacterial biofilms. These resilient structures act as protective shields for bacteria, making them exceptionally difficult to eradicate.
Biofilms are known to increase bacterial resistance to antibiotics by up to 1,000 times. The newly discovered mechanism targets the assembly of these protective biofilms rather than directly attacking the bacteria. This approach bypasses the common route for developing antimicrobial resistance and offers a promising new strategy for treating chronic infections.
This discovery, published in 'Proceedings of the National Academy of Sciences,' opens avenues for developing therapies inspired by the body's own molecular defenses. Such treatments could offer safer, more sustainable options for persistent infections, potentially complementing or replacing traditional antibiotics while also exhibiting wound-healing properties.
