Your Genes Might Shape Your Roommate's Gut

New research indicates that our gut microbiome is influenced by those we live with, challenging the notion that gut health is solely an individual concern. A comprehensive study involving over 4,000 rats, published in Nature Communications on December 18, revealed that gut bacteria composition is shaped by both an individual's genes and the genes of their cage mates.

Scientists identified specific gene-microbe links, such as the St6galnac1 gene promoting the growth of the bacterium Paraprevotella. This connection, along with others involving mucin genes and the Pip gene, demonstrated how genetic factors can encourage the proliferation of certain bacteria. These bacteria can then be transmitted through social contact, leading to 'indirect genetic effects' that significantly amplify the overall genetic influence on gut health.

While conducted on rats, these findings have potential implications for human health. If shared gut microbes are influenced by genetic predispositions that spread socially, an individual's genetic makeup could indirectly impact the health of their household members. The study also hints at possible links between these genetic-microbial interactions and diseases like COVID-19 and IgA nephropathy.