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Genomic Research Skewed: High-Income Nations Dominate Studies
23 Dec
Summary
- Over 80% of global genomic disease studies are in high-income countries.
- Fewer than 5% of studies are from low and middle-income countries.
- Infectious diseases represent only 3% of genomic research.
A comprehensive global analysis by the World Health Organization highlights a significant disparity in genomic research, with high-income countries dominating over 80% of studies on diseases. Conversely, low and middle-income countries (LMICs) account for less than five percent, despite being included as study sites in multicountry initiatives. China, the United States, and Italy lead in registered genomic clinical studies.
While cancer, rare diseases, and metabolic disorders comprise over 75% of genomic research, infectious diseases like tuberculosis, HIV, and malaria are significantly underrepresented, making up just three percent of studies. This trend signifies a missed opportunity to apply genomic insights to critical global health priorities, particularly in low-resource settings.
The report also underscores a lack of demographic diversity, with over 75% of studies focusing on adults aged 18-64, while children and older adults are largely excluded. The WHO advocates for increased investment in LMICs, greater representation of diverse populations, and alignment of research agendas with local disease burdens to ensure health equity.
