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Alzheimer's Reversed in Mice: Cellular Energy Key
11 Jan
Summary
- Cellular energy molecule NAD+ deficiency linked to Alzheimer's onset.
- Restoring NAD+ levels reversed advanced Alzheimer's in mice.
- Cognitive function and tau markers improved in treated mice.
Alzheimer's disease, long considered irreversible, may now have a potential pathway to reversal. Recent research has identified a critical role for the cellular energy molecule NAD+ in brain health. Studies indicate that a deficiency in NAD+ is a major factor in the development of Alzheimer's disease.
Scientists successfully replenished NAD+ levels in mice exhibiting advanced stages of Alzheimer's. This intervention led to a reversal of the disease and a restoration of cognitive abilities. The findings suggest a novel therapeutic approach targeting cellular energy metabolism.
Further analysis revealed that the treated mice also exhibited normalized blood levels of phosphorylated tau 217. This protein abnormality is increasingly recognized as a significant biomarker for Alzheimer's disease in humans, offering hope for future treatments.
