What protein did researchers activate to improve brain blood flow in Alzheimer's mice?

Researchers activated the Piezo1 protein, a mechanosensitive ion channel functionally expressed in blood vessels.

Why is improving blood flow important for Alzheimer's treatment?

Reduced blood flow and impaired vascular responses in the brain are early features of Alzheimer's that contribute to the disease's progression.

What potential therapeutic strategies could arise from this Alzheimer's study?

This research offers a promising new therapeutic strategy for humans, potentially leading to more effective treatments or even a cure for Alzheimer's disease.

Home / Science / Alzheimer's Breakthrough: New Study Targets Blood Flow

Alzheimer's Breakthrough: New Study Targets Blood Flow

7 Feb

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Summary

Researchers activated a protein to improve brain blood flow in Alzheimer's mice.
Improved blood flow is crucial for combating early Alzheimer's symptoms.
This study offers hope for new Alzheimer's therapeutic strategies.

Alzheimer's Breakthrough: New Study Targets Blood Flow

University of Miami researchers have made a significant stride in Alzheimer's treatment by successfully improving cerebrovascular function in a mouse model of the disease. Published in December 2025, the study focused on activating Piezo1, a protein found in blood vessels. This activation led to improved microvascular flow and neurovascular coupling, addressing early features of Alzheimer's that contribute to its progression.

The research team, comprising Ph.D. students Supriya Chakraborty and Zeynad Tabrizi, utilized pharmacological methods to enhance functional hyperemia, a vital increase in blood flow to the brain and muscles. Their findings suggest this approach holds substantial promise as a therapeutic strategy for humans suffering from Alzheimer's.