Home / Science / Alcohol Satisfaction Secret Unlocked by Science
Alcohol Satisfaction Secret Unlocked by Science
16 Feb
Summary
- A liver hormone, FGF-21, triggers satisfaction after drinking.
- Weakened satisfaction mechanisms drive excessive alcohol intake.
- A sugar, allulose, boosted FGF-21 and reduced alcohol use.

Researchers have identified a critical mechanism linked to alcohol consumption and satisfaction. A hormone produced by the liver, known as FGF-21, stimulates brain nerves to generate a sense of contentment after drinking. The study, involving experiments with mice, revealed that a diminished response in this satisfaction pathway contributes to increased alcohol intake, particularly in mice exhibiting alcohol addiction.
Further investigations demonstrated that administering allulose, a type of sugar, significantly promoted the secretion of FGF-21. This intervention led to a notable reduction in alcohol consumption among both normal and alcohol-dependent mice, with effects lasting up to a week in addicted subjects. Scientists are now planning to develop a drug that stimulates FGF-21 secretion, aiming to test its efficacy in treating alcohol addiction.




