Weight-Loss Jabs: Stopping May Cause Fatigue

Millions are using popular weight-loss injections, but discontinuing these treatments can lead to noticeable health changes, including fatigue.

While tiredness is a common side effect of medications such as semaglutide (Wegovy) and tirzepatide (Mounjaro) during treatment, it may also arise after stopping. The NHS advises speaking with a doctor before halting these drugs, rather than stopping abruptly, as sudden cessation can impact blood sugar levels, especially for those with type 2 diabetes.

Research indicates that weight regain is a significant concern following the cessation of semaglutide treatment. A study found participants regained approximately two-thirds of their lost weight within a year of stopping the medication. However, individual results vary, and support is recommended to help maintain a healthy weight post-treatment.

Persistent or unexplained fatigue should not automatically be attributed to medication history. The NHS advises consulting a GP if tiredness continues for several weeks or affects daily life, as fatigue can stem from various causes.