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Weight-Loss Drug Sparks Severe Anxiety Crisis
24 Feb
Summary
- A woman experienced severe anxiety and depression after increasing her dosage.
- She lost 49lbs over 10 months on a lower dose of the drug.
- Her mental health improved significantly after returning to the lower dose.
Jade Martin, a UK mother, experienced severe anxiety and depression after adjusting the dosage of a weight-loss drug. She had initially started Mounjaro in January 2025, successfully losing 49 pounds over ten months and weighing 175 pounds.
In March 2025, Martin increased her Mounjaro dosage from 2.5mg to 5mg, following a standard protocol. This change triggered intense anxiety and depression, impacting her sleep and overall well-being. Her doctor subsequently reduced her dose back to 2.5mg.
When she attempted to increase the dosage again in July 2025, the severe mental health side effects recurred. She decided to permanently remain on the 2.5mg dose, accepting a slower but healthier weight loss rate.
Martin emphasized that her mental health is paramount, stating no amount of weight loss is worth sacrificing her well-being. She advocates for not rushing dose increases and for being comfortable with normal hunger.
Anxiety and depression are not officially listed as side effects of Mounjaro, which mimics hormones GIP and GLP-1 to promote fullness. Martin's experience highlights a personal adverse reaction to a higher dose.
She now feels like herself again on the lower dose, embracing a healthier relationship with food and her body. Her advice is to listen to one's body and not hasten the process of dose escalation.
