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US Sees Longest Drop in Overdose Deaths
13 May
Summary
- Overdose deaths decreased for the third consecutive year.
- New potent drugs like 'cychlorphine' are emerging.
- Some federal programs aiding overdose prevention are being cut.

Preliminary government data indicates a positive trend in the fight against the overdose epidemic, with U.S. drug overdose deaths falling for the third consecutive year. The total number of deaths in the past year was approximately 70,000, representing the longest decline in decades and returning to pre-pandemic levels seen in 2019. This reduction spans various drug types, including fentanyl, cocaine, and methamphetamine.
Despite this progress, the overall number of overdose deaths remains high, and experts caution that this positive trajectory could reverse if efforts are reduced. The emergence of new and potent synthetic opioids, such as cychlorphine—reportedly ten times stronger than fentanyl—poses a significant new threat. Additionally, veterinary sedatives like xylazine are appearing in the illicit drug supply, complicating treatment and posing additional health risks.
Compounding these challenges, some federal programs aimed at reducing overdose deaths and infections are experiencing significant cuts. Notably, funding for fentanyl and xylazine test strips has been discontinued, a move criticized by harm reduction advocates who view these tools as evidence-based. Officials state a shift in strategy, moving away from facilitating illicit drug use, towards methods like wastewater testing and AI for identifying high-risk individuals.