How does exercise affect muscle during weight loss?

Exercise during weight loss can actually have a positive effect on muscle, according to the study. The researchers found that a severe calorie deficit combined with aerobic exercise led to increased mitochondrial proteins and reduced collagen in the muscle, signs of improved metabolic function and youthfulness.

What evolutionary adaptation helps muscles thrive during calorie restriction?

The researchers believe the muscle's ability to maintain and even improve its function during periods of low food availability may be an evolutionary adaptation. This would have been essential for human survival in the past, as the ability to move efficiently during times of scarcity would have been crucial for activities like foraging and hunting.

How can older adults benefit from exercising during weight loss?

The study suggests that older adults, who are more vulnerable to muscle loss, may especially benefit from exercising while losing weight. The researchers found that the muscle changes observed in the study, such as increased mitochondrial proteins and reduced collagen, are linked to healthier aging, indicating that exercise can help preserve muscle quality in older individuals trying to lose weight.

Home / Health / Muscle-Preserving Secrets Revealed: Exercise Boosts Metabolic Health During Weight Loss

Muscle-Preserving Secrets Revealed: Exercise Boosts Metabolic Health During Weight Loss

13 Nov

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Summary

Muscle loss during weight loss can impair long-term weight management
Aerobic exercise during calorie restriction may improve muscle quality
Muscle responds with increased mitochondrial proteins and reduced collagen

Muscle-Preserving Secrets Revealed: Exercise Boosts Metabolic Health During Weight Loss

According to a study published in November 2025, exercise during weight loss may have surprising benefits for muscle health, contrary to common assumptions. The research, conducted by a team of scientists, examined how the human body responds to a severe calorie deficit combined with regular aerobic exercise.

The study involved 10 healthy young men who underwent two five-day trials - one where they consumed enough calories to maintain their weight, and another where their daily calorie intake was reduced by 78%, a severe energy deficit. During both trials, the participants completed 90-minute low- to moderate-intensity cycling sessions three times.