How does UV radiation from the sun cause skin cancer according to the new study?

The study found UV exposure lowers a protective protein called YTHDF2 and triggers inflammatory pathways by affecting RNA molecules, potentially leading to cancer.

What is YTHDF2 and why is it important for skin health?

YTHDF2 is a protein that acts as a gatekeeper, preventing normal skin cells from turning cancerous. UV exposure reduces its levels.

Can new treatments be developed from this skin cancer research?

Yes, researchers are exploring potential new treatments and prevention strategies by targeting the interactions between RNA and proteins that influence inflammation.

Home / Health / Sun Study: UV Rays Disrupt Skin's Cancer Defense

Sun Study: UV Rays Disrupt Skin's Cancer Defense

4 Dec, 2025

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Summary

UV exposure lowers protective protein YTHDF2, a gatekeeper.
Inflammation worsens as RNA triggers cancer pathways.
New treatments may target RNA and protein interactions.

Sun Study: UV Rays Disrupt Skin's Cancer Defense

New research published in Nature Communications has detailed the mechanisms by which ultraviolet (UV) radiation can lead to skin cancer. Scientists investigated the impact of UV rays on human and mouse cells, uncovering that prolonged exposure significantly diminishes YTHDF2, a protein vital for preventing normal skin cells from becoming cancerous. This reduction in YTHDF2 appears to intensify UV-induced inflammation, creating a cycle conducive to cancer development.

Furthermore, the study identified that cancer cells exhibit elevated levels of ribonucleic acid (RNA), which further activates inflammatory pathways linked to cancer. This finding suggests that UV radiation not only damages DNA but also disrupts RNA molecules. Researchers are hopeful that these insights could pave the way for novel therapeutic and preventative strategies focused on reversing UV damage to RNA.

While the findings highlight the risks of excessive sun exposure, experts emphasize that sun exposure also offers health benefits, such as aiding vitamin D production. The consensus remains that balance and moderation are key. Dermatologists advise diligent sun protection through sunscreen, protective clothing, and seeking shade to mitigate risks and maintain overall skin health.