What is the CHEK2 gene mutation and its link to breast cancer?

The CHEK2 gene mutation is a genetic alteration linked to a significantly increased risk of developing breast cancer and other cancers.

Why did Kate and Elizabeth Singletary need double mastectomies?

Both sisters were diagnosed with breast cancer and carried the CHEK2 gene mutation, prompting aggressive surgical intervention to remove cancerous tissue and reduce future risk.

What are the recommended screening protocols for high-risk individuals like the Singletary sisters?

High-risk individuals are advised to start mammograms at an earlier age, often alternating with MRIs, and should consider genetic testing if there is a family history.

Home / Health / Sisters Diagnosed with Breast Cancer Months Apart

Sisters Diagnosed with Breast Cancer Months Apart

24 Nov

•

Summary

Two North Carolina sisters diagnosed with breast cancer within months.
Both sisters found to carry the CHEK2 gene mutation.
Each underwent urgent double mastectomies as treatment.

Sisters Diagnosed with Breast Cancer Months Apart

Two sisters from North Carolina, Kate and Elizabeth Singletary, both 27, faced a daunting breast cancer diagnosis in close succession. Their journey began when Kate discovered a lump in March 2024, leading to a Stage III diagnosis. Shortly after, genetic testing revealed both sisters carried the CHEK2 gene mutation. This discovery heightened their risk and was followed by Elizabeth’s own Stage I breast cancer diagnosis approximately six months after Kate's initial detection.

This shared genetic predisposition and diagnosis led both sisters to undergo urgent double mastectomies within a five-day period. They recovered together, supporting each other through post-operative care. Kate's treatment involved chemotherapy, surgery, and radiation, while Elizabeth also received aggressive treatment. Their experience underscores the aggressive nature of breast cancer in younger patients and the impact of inherited mutations.