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Sexually Transmitted Shigella Alarms Health Officials
24 Oct
Summary
- Antibiotic-resistant shigellosis infections are rising, primarily sexually transmitted.
- The infection is increasingly spreading among men who have sex with men.
- Extensively drug-resistant cases are becoming untreatable, posing risks.

Antibiotic-resistant shigellosis infections are on the rise in the United States, with a significant and increasing proportion being sexually transmitted. This gastrointestinal illness, caused by Shigella bacteria, typically presents with acute diarrhea, vomiting, stomach pain, and fever. While most cases resolve on their own, severe instances require antibiotics and hospitalization.
The traditional fecal-oral route of transmission from contaminated food or water is now being supplemented by sexual transmission, a method for which standard hygiene practices are ineffective. This specific transmission pathway is most commonly observed among men who have sex with men, who may be unaware of the heightened risk.
Public health data from 2026 indicates nearly 15,000 diagnosed cases across 47 states, mirroring the previous year's numbers. However, a more alarming trend is the rise in antibiotic-resistant infections. Extensively drug-resistant (XDR) strains have increased between 2011 and 2023, particularly among adult men. These XDR cases pose a severe threat, especially to vulnerable populations like children and the unhoused, as the infection is transitioning from treatable to nearly untreatable.