Home / Health / Scientists Grow New Teeth in Mice, Human Trials Underway
Scientists Grow New Teeth in Mice, Human Trials Underway
27 Jun
Summary
- Drug targets USAG-1 protein to stimulate new tooth growth.
- First-in-human safety trial of TRG035 drug completed in Japan.
- Toregem BioPharma aims for practical use by 2030, targeting rare conditions first.
Scientists are exploring a novel approach to tooth regeneration by targeting the USAG-1 protein, which limits tooth formation. In animal studies, blocking this protein has successfully stimulated the growth of new teeth. This research has progressed to human testing, with Toregem BioPharma completing a Phase I clinical safety study of its drug, TRG035, in Japan.
The company's goal is to offer a "third choice" alongside dentures and implants for tooth replacement. While the initial human trial focused on safety, further research is required to prove the drug's efficacy in regrowing functional teeth in people. Toregem BioPharma is pursuing funding to support Phase II trials and aims for practical use by 2030.
Initial applications are anticipated for patients with congenital tooth agenesis, a condition where individuals are born missing multiple permanent teeth. This rare disease affects approximately 0.1 percent of the population. The company has secured significant funding to advance its research and development, including preparations for U.S. clinical trials.
