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Home / Health / Psychedelics Outshine Cannabis for OCD Relief

Psychedelics Outshine Cannabis for OCD Relief

13 Dec, 2025

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Summary

  • Psychedelics, particularly psilocybin, show stronger evidence for OCD treatment efficacy.
  • Cannabis, including THC and CBD, offers less lasting relief for OCD symptoms.
  • Brain network interactions and therapeutic 'journey' framing may explain differing results.
Psychedelics Outshine Cannabis for OCD Relief

Emerging research indicates that psychedelic substances, particularly psilocybin, demonstrate greater potential as treatments for obsessive compulsive disorder (OCD) compared to cannabis. A review of available studies found stronger evidence supporting the efficacy of psilocybin in alleviating OCD symptoms.

These findings suggest that the unique way psilocybin interacts with specific brain networks, like the default mode network, may offer more profound therapeutic benefits than cannabinoids. This difference is also attributed to the supportive, journey-oriented approach often used in psychedelic therapy studies, which is less common in cannabis research.

While challenges such as the legal status of psilocybin and the phenomenon of 'functional unblinding' persist in research, experts are optimistic about developing rigorous, ethical trials. The goal is to establish psychedelics as a serious, evidence-based treatment option for individuals with OCD.

Disclaimer: This story has been auto-aggregated and auto-summarised by a computer program. This story has not been edited or created by the Feedzop team.
Yes, recent research suggests psilocybin shows significant promise for treating OCD symptoms by affecting brain networks involved in rumination.
Dr. Van Ameringen theorizes psilocybin impacts brain connectivity differently than cannabis, potentially offering more lasting relief for OCD.
Challenges include psilocybin's legal status as a Schedule I substance and the difficulty in maintaining blind study conditions due to its potent effects.

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