What did the FDA panel say about SSRIs and pregnancy?

A July FDA panel discussion raised concerns linking SSRIs to increased risks of miscarriage and birth defects, though these claims were widely disputed by medical organizations.

Are antidepressants safe for pregnant women?

Many medical experts state that SSRIs are generally safe and often life-saving for pregnant women with depression or anxiety, with extensive research supporting their use.

What are the risks of untreated depression in pregnancy?

Untreated maternal depression is a leading cause of maternal death and can lead to premature birth, low birth weight, and increased risk of substance misuse and suicide.

Home / Health / Pregnancy SSRI Debate: Fear vs. Fact

Pregnancy SSRI Debate: Fear vs. Fact

14 Dec, 2025

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Summary

FDA panel raised concerns about SSRIs in pregnancy.
Experts say claims link drugs to birth defects are unfounded.
Untreated maternal depression poses significant risks.

A recent Food and Drug Administration (FDA) panel discussion concerning Selective Serotonin Reuptake Inhibitors (SSRIs) during pregnancy has ignited significant debate and concern among medical professionals and patient advocates. While some panelists voiced apprehension about potential risks such as miscarriage and birth defects, prominent medical associations have strongly refuted these claims, labeling them "outlandish and unfounded."

The controversy highlights a critical issue: the significant number of women experiencing depression and anxiety during or after pregnancy, many of whom do not receive adequate treatment. Experts emphasize that untreated maternal mental health conditions, including suicide, are a leading cause of death, underscoring the importance of accessible and appropriate care, including the use of SSRIs.

Physicians and therapists are concerned that the panel's discussion, coupled with perceived misinformation, will exacerbate the existing stigma surrounding antidepressant use in pregnancy, potentially leading more mothers to avoid necessary treatment. Organizations like the American College of Obstetricians and Gynecologists stress that SSRIs are among the most well-studied medications in pregnancy and are considered a vital tool for maternal well-being.