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Obesity Fuels Aggressive Breast Cancer Spread
30 May
Summary
- Obesity linked to more aggressive, invasive breast cancer.
- Higher enzyme Sulfatase 2 found in tumors of women with obesity.
- Inflammation around tumors may also accelerate growth in obese women.
Research from Oklahoma University indicates that obesity may drive more aggressive breast cancer in women. Unique changes observed in women with obesity appear to promote invasive breast cancer, leading it to spread into surrounding breast tissue more readily.
The study identified increased inflammation in the areas surrounding tumors. Immune cells, normally disease fighters, can be reprogrammed by tumors to support growth. Additionally, cancer cells in women with obesity demonstrated better survival under stress.
Researchers also found higher levels of the enzyme Sulfatase 2 within tumor cells. This enzyme has been previously associated with various cancers. Further investigation is planned to clarify its specific role in invasive breast cancer development.
While breast cancer survival rates have improved, diagnoses of invasive breast cancer remain a concern. Approximately 321,910 new cases are anticipated this year. Understanding obesity's role could lead to better patient treatments and risk assessment.
