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Nasal Spray Reverses Brain Aging in Mice
27 Apr
Summary
- Microscopic particles in a nasal spray reduced brain inflammation.
- Mice showed memory and cognitive improvements within weeks.
- Two doses provided benefits lasting for months after treatment.
Researchers at Texas A&M University have developed a novel nasal spray therapy that appears to reverse age-related brain decline. The treatment targets "neuroinflammaging," a chronic inflammation linked to cognitive loss.
In a study, mice equivalent to 60-year-old humans received the spray containing stem cell-derived particles. Within weeks, treated mice exhibited reduced brain inflammation and enhanced memory and cognitive abilities.
This therapy utilizes extracellular vesicles to deliver microRNAs past the brain's protective barrier, suppressing inflammation and boosting cell energy. The findings, while early, suggest a potential for a simple, two-dose treatment.
Given the rising prevalence of age-related brain diseases like dementia and Alzheimer's, this research offers a potential breakthrough. Scientists aim to develop this therapy for human testing, moving towards a non-invasive treatment option.
