How does Mounjaro affect the brain's reward system?

Mounjaro, a weight-loss drug, has been shown to suppress low-frequency brain signals in the nucleus accumbens, a part of the brain's reward system, which are linked to episodes of intense food preoccupation and cravings in obese patients.

What did the study on Mounjaro's effects find?

The study, conducted by researchers at the University of Pennsylvania, analyzed brain activity in 3 severely obese patients and found that Mounjaro and electrical stimulation to the brain's reward system reduced the "food preoccupation" signals associated with eating control.

How long did the effects of Mounjaro last on the patient's brain signals and food cravings?

While Mounjaro initially resulted in a decline in the patient's delta-theta brain activity and food cravings, these effects returned a few months later, suggesting the drug's impact on the brain's eating control signals may be temporary.

Home / Health / Mounjaro Jab May Curb Food Cravings by Altering Brain Signals, Study Finds

Mounjaro Jab May Curb Food Cravings by Altering Brain Signals, Study Finds

18 Nov

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Summary

Mounjaro suppresses brain signals linked to eating control and food cravings
Study analyzed brain activity of 3 obese patients, 1 on Mounjaro
Electrical stimulation and Mounjaro reduced "food preoccupation" brain signals

Mounjaro Jab May Curb Food Cravings by Altering Brain Signals, Study Finds

According to a first-of-its-kind study published on 2025-11-18T06:46:42+00:00, the weight-loss drug Mounjaro may help slash food cravings by suppressing brain signals linked to eating control. Researchers at the University of Pennsylvania placed electrodes in the brains of 3 severely obese patients to study the drug's impact on the brain's reward system.

The study found that episodes of intense food preoccupation and cravings were associated with low-frequency brain signals, known as delta-theta activity, in the nucleus accumbens. In 2 patients, electrical stimulation to this brain region reduced these signals. The third patient, who was taking Mounjaro for diabetes after weight-loss surgery, also experienced a decline in delta-theta activity and food cravings.