What is Lynch syndrome and who is at risk?

Lynch syndrome is a hereditary condition caused by genetic mutations that significantly increases the risk of several cancers, most notably colorectal cancer.

How did Tiffany Graham Charkosky discover Lynch syndrome?

Tiffany Graham Charkosky discovered she had Lynch syndrome after her uncle's diagnosis, prompted by her mother's earlier death from colon cancer.

What are the risks associated with Lynch syndrome?

Lynch syndrome increases the likelihood of developing colorectal cancer by 40-80%, and also raises the risk for endometrial, breast, stomach, and other cancers.

Home / Health / Family's Genetic Curse: 80% Cancer Risk Unveiled

Family's Genetic Curse: 80% Cancer Risk Unveiled

2 Dec, 2025

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Summary

Lynch syndrome dramatically increases cancer risk up to 80%.
Genetic testing is the only way to detect Lynch syndrome.
Colorectal cancer rates have surged in young Americans.

Family's Genetic Curse: 80% Cancer Risk Unveiled

Tiffany Graham Charkosky's family history of colon cancer, which claimed her mother at 31 and uncle at 46, led to a startling discovery: Lynch syndrome. This hereditary genetic mutation significantly elevates the risk of developing various cancers, including colorectal, by up to 80%. Diagnosed around age 30, Tiffany faced a daunting reality, prompting her to undergo rigorous screenings and preventative surgeries.

Lynch syndrome affects approximately one in 300 Americans, yet most remain unaware due to the reliance on genetic testing. This lack of awareness is particularly concerning as colorectal cancer diagnoses are surging among young adults, with rates for teenagers already seeing a dramatic increase. The syndrome's genetic basis lies in mutations that impair DNA repair mechanisms, leading to uncontrolled cell growth.

Inspired by her journey, Tiffany authored 'Living Proof: How Love Defied Genetic Legacy' to empower others facing similar risks. Her experience underscores the critical importance of genetic awareness and proactive health management in confronting inherited cancer predispositions, offering hope and agency to those navigating this challenging diagnosis.

Disclaimer: This story has been auto-aggregated and auto-summarised by a computer program. This story has not been edited or created by the Feedzop team.

Family's Genetic Curse: 80% Cancer Risk Unveiled

2 Dec, 2025

•

Summary

Lynch syndrome dramatically increases cancer risk up to 80%.
Genetic testing is the only way to detect Lynch syndrome.
Colorectal cancer rates have surged in young Americans.

Disclaimer: This story has been auto-aggregated and auto-summarised by a computer program. This story has not been edited or created by the Feedzop team.