Low Liver Enzymes Signal Colorectal Cancer?

Routine blood tests might reveal unexpected clues about the risk of early-onset colorectal cancer. New research indicates that adults under 45 with lower levels of liver enzymes AST and ALT were more likely to be diagnosed with this cancer. This association was unexpected, as high liver enzymes usually raise health concerns. Researchers stress that this finding highlights a correlation, not causation, and does not warrant changes to existing screening guidelines. The study suggests these enzyme levels could reflect underlying physiological factors, prompting further investigation into the rise of colorectal cancer among younger adults.

The analysis examined health data from over 11,000 adults in the United States. It found that AST levels below 14 units per liter were associated with a 65% higher likelihood of early-onset colorectal cancer diagnosis, while ALT levels below 14 showed a 68% higher likelihood. Conversely, higher levels of AST and ALT were linked to a lower risk. Experts caution against altering screening practices based on these results alone. They recommend focusing on overall health and adhering to established screening protocols, such as starting at age 45 for average-risk individuals.