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Japan Sees Surge in Therapy-Related Leukemia
6 Apr
Summary
- Therapy-related leukemia rates rose significantly in Japan between 1990 and 2020.
- Breast cancer treatment was increasingly linked to higher tAML risk over time.
- The incidence of tAML nearly tripled over three decades in Japan.
A population-based study conducted in Japan has identified a steady rise in therapy-related acute myeloid leukemia (tAML) rates over the past three decades. The findings, published recently, indicate that cancer treatments, including chemotherapy and radiation, may elevate the risk of developing this aggressive blood and bone marrow cancer. Investigations analyzed data from 9,841 AML patients diagnosed between 1990 and 2020.
The study revealed that tAML incidence increased from 0.13 per 100,000 population in 1990 to 0.36 per 100,000 by 2020. This represents a near tripling over the observed period, with the proportion of tAML cases within overall AML diagnoses also nearly doubling. Breast cancer treatment emerged as a significant primary cancer treated before tAML developed, with its proportion notably increasing over time.
