How do diseased kidneys harm the heart?

Diseased kidneys release tiny, toxic particles called extracellular vesicles into the bloodstream, which can damage heart tissue.

What did researchers discover about the kidney-heart connection?

Researchers found that failing kidneys release microscopic sacs carrying harmful RNA that directly affects heart tissue, establishing a causal link.

Can the effects of these kidney-released particles be reversed?

Early studies in mice suggest that reducing these harmful extracellular vesicles can improve heart function in animals with diseased kidneys.

Home / Health / Kidney Disease's Toxic Secret for Your Heart Revealed

Kidney Disease's Toxic Secret for Your Heart Revealed

1 Feb

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Summary

Diseased kidneys release toxic particles harmful to the heart.
These particles contain RNA that damages heart tissue.
Reducing these particles improved heart function in mice.

Kidney Disease's Toxic Secret for Your Heart Revealed

A groundbreaking study has revealed a molecular mechanism explaining the high incidence of heart failure among patients with chronic kidney disease. Researchers identified that damaged kidneys release microscopic, liquid-filled sacs called extracellular vesicles. These particles, carrying toxic RNA, travel through the bloodstream and directly harm heart tissue.

This discovery offers a causal link, moving beyond shared risk factors like diabetes and high blood pressure. In laboratory tests, reducing these vesicles in mice with kidney disease led to improved heart function. Scientists believe this breakthrough could lead to earlier diagnosis and more personalized treatments for kidney patients at risk of heart complications.

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