Home / Health / Immune Protein Halts Kidney Cyst Growth
Immune Protein Halts Kidney Cyst Growth
19 Nov
Summary
- An immune protein called dIgA can enter and inhibit kidney cyst growth.
- The protein targets receptors that enable cyst-lining cells to multiply.
- This protein also triggers cell death, potentially reversing disease progression.
Scientists may have discovered a novel way to halt the progression of polycystic kidney disease (PKD). Research funded by the National Institutes of Health and the US Department of Defense indicates that an immune protein, dimeric immunoglobulin A (dIgA), shows promise in inhibiting the growth of kidney cysts.
The study, published in Cell Reports Medicine, found that dIgA can enter these cysts and block their relentless expansion. This is achieved by targeting specific receptors within the cyst-lining cells that drive their multiplication. These cells typically secrete growth factors, creating a self-stimulating cycle that dIgA can interrupt.
Remarkably, the research also revealed that dIgA can induce the death of cyst epithelial cells. This dual action—inhibiting growth and promoting cell death—suggests a potential to not only halt but also reverse the disease's progress. Although trials are pending human application, this discovery offers significant hope for managing an otherwise incurable genetic condition.
