India's Stem Cell Gap: Patients Await Lifesaving Matches

For individuals requiring a stem-cell transplant without a compatible family donor, registries offer a pathway to potential unrelated donors. Experts emphasize that India must expand and diversify its donor pool to enhance the likelihood of finding matches. Recently, Tamil Nadu announced the establishment of its own stem cell/bone marrow registry, addressing the urgent need for approximately 50 patients currently on the waitlist in the state.

A stem-cell donor registry databases individuals willing to donate their stem cells. Their Human Leukocyte Antigen (HLA) profiles are recorded for comparison with patients. Finding a suitable HLA match is critical for successful transplants, especially for those with blood cancers or disorders like thalassemia.

While India has several independent registries, the overall donor numbers and diversity are insufficient. These registries are connected to international networks, allowing searches beyond national borders. However, the genetic variability within India necessitates a registry that reflects this diversity to better serve all patient communities and improve transplant outcomes.