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IBS Meds Tied to Higher Death Risk, Study Finds
9 Apr
Summary
- Long-term antidepressant use linked to 35% higher death risk.
- Opioid anti-diarrheal diphenoxylate tied to 89% increased death risk.
- OTC loperamide associated with double the risk of death.
A recent study indicates that several frequently used medications for irritable bowel syndrome (IBS) might be associated with an elevated risk of death.
Researchers analyzed health records of nearly 670,000 US adults diagnosed with IBS between 2005 and 2023. They found that long-term antidepressant use was linked to a 35 percent higher risk of all-cause mortality compared to non-users.
Furthermore, the opioid anti-diarrheal diphenoxylate was associated with an 89 percent increased risk of death. Over-the-counter loperamide, commonly sold as Imodium, was linked to double the risk of death from any cause.
The study authors emphasize that these associations do not confirm direct causation but suggest the medications may be linked to serious adverse events like heart attack, falls, and stroke. They advise IBS patients to discuss potential risks with their healthcare providers for personalized treatment plans.
