Home / Health / HRT: No Link to Dementia, Says New Study
HRT: No Link to Dementia, Says New Study
23 Dec, 2025
Summary
- HRT does not increase or decrease dementia risk.
- A review analyzed 10 studies with over one million women.
- Findings will inform upcoming WHO dementia prevention guidelines.
New scientific analysis indicates that hormone replacement therapy (HRT) neither increases nor decreases the likelihood of developing dementia. Researchers from the UK, Ireland, Switzerland, Australia, and China reviewed 10 studies involving more than a million women, concluding that HRT's prescription should not be influenced by dementia prevention. This finding offers clarity amidst previous conflicting research and public debate.
The review examined the impact of HRT on mild cognitive impairment (MCI) and dementia in both pre- and post-menopausal women, including those with early menopause or premature ovarian insufficiency. The study found no significant association between HRT use and the risk of MCI or dementia, regardless of the timing, duration, or type of hormone therapy used.
Experts anticipate these findings will significantly influence the upcoming World Health Organisation guidelines on dementia risk reduction, expected in 2026. While acknowledging the need for further high-quality, long-term research, the current evidence suggests HRT's role in dementia risk is neutral, allowing for prescription based on other established benefits and risks.
