Gene Mutation Guarantees Cancer: Woman's Fight for Life

Hannah Simpson, aged 32, has received a stark medical prognosis, being told she has an "up to 100% chance" of developing hereditary cancer. This risk stems from a mutation in the APC gene, which causes familial adenomatous polyposis (FAP), a condition that previously led to the death of her mother, Jeanette Simpson, in 2022. Hannah's family history also includes her late granddad, Terry Cook, who had hereditary cancer. The diagnosis has prompted Hannah to consider significant, life-altering surgery to mitigate her high risk. She describes the genetic link as a "proper kick in the stomach," intensifying the grief of losing her mother.

Recognizing the profound impact of such diagnoses, Hannah has joined the "It Starts With You" community choir, an initiative born from BBC Radio Derby's campaign. The choir aims to support individuals and families affected by hereditary cancer, a cause amplified by the story of breakfast presenter Becky Measures, who underwent preventative surgery due to carrying the BRCA1 gene mutation. Hannah found solace and community in the choir, stating, "The minute I walked into that practice, I was like, 'OK, I've done the right thing. And this is where I belong.'" The choir recently debuted a song produced by Grammy award-winning composer Eliot Kennedy, broadcast across local BBC stations in England on Sunday, in hopes of helping others feel less alone.