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Researchers Seek Breakthroughs in Mental Illness Treatment

Summary

  • No new treatments for schizophrenia, bipolar, psychosis in 50+ years
  • Life expectancy 10-20 years less for those with serious mental illness
  • Study collects data from 600 people to understand illness causes
Researchers Seek Breakthroughs in Mental Illness Treatment

According to a report published on 2025-11-14T12:46:50+00:00, researchers at Cardiff University are conducting a groundbreaking study that could pave the way for improved treatment and diagnosis of serious mental illnesses. The study is collecting data from 600 participants in an effort to better understand the underlying causes of conditions like schizophrenia, bipolar disorder, and psychosis.

This research comes at a critical time, as there have been no truly new treatments for these illnesses since the introduction of antipsychotics and lithium over 50 years ago. Currently, people with serious mental health conditions have a life expectancy that is 10 to 20 years younger than the general population, and existing medications can have severe side effects.

"If we can get to the cause, then we can start looking at new treatments," said Neil Harrison, a professor of psychiatry and neuroimaging at Cardiff University. The study aims to identify new genomic variants and examine brain structure and activity in an effort to uncover the underlying biological, psychological, and social mechanisms behind these disorders.

Carina, who was diagnosed with bipolar disorder at age 23, has experienced the challenges firsthand. She has been detained under the Mental Health Act nine times and has endured long hospital stays, as well as debilitating side effects from her medication. Carina is hopeful that the research will lead to treatments that allow people with psychotic disorders to have the same life expectancy as the general population.

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The Cardiff University study is investigating the underlying causes of serious mental illnesses like schizophrenia, bipolar disorder, and psychosis in an effort to develop new and better treatments.
According to the article, there have been no truly new treatments for schizophrenia, bipolar disorder or psychosis since the introduction of antipsychotics and lithium more than 50 years ago.
Carina, who was diagnosed with bipolar disorder at age 23, has been detained under the Mental Health Act nine times and has endured long hospital stays and debilitating side effects from her medication. She is hopeful the research will lead to treatments that allow people with psychotic disorders to have the same life expectancy as the general population.

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