Painkiller Combos Pose Poison Risk to Millions

Millions of Britons taking common gabapentinoid painkillers are at risk of drug poisoning due to interactions with other prescribed medications. A University College London study revealed that combining gabapentinoids with sedatives like benzodiazepines can double the risk of hospitalisation. Similarly, mixing these drugs with opioids is associated with a 30% increased risk.

Despite these significant dangers, the study found that nearly 90% of patients were prescribed opioids with gabapentinoids, and over half also received benzodiazepines. These medications, including gabapentin and pregabalin, are increasingly prescribed globally, with over 4.5 million people in England receiving them annually. Researchers analysed UK data from over 16,000 patients, identifying that drug poisoning symptoms can range from confusion to seizures and death.

Lead author Dr. Kenneth Man emphasized that while gabapentinoids are seen as a safer alternative to opioids, substantial risks remain. The study highlights that clinicians must remain vigilant, especially when patients are on multiple medications. Recent warnings from the Medicines and Healthcare products Regulatory Agency (MHRA) also increased alerts on gabapentinoids regarding addiction and dependence.