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Gabapentin: The Double-Edged Sword of Pain Relief
27 Jan
Summary
- Gabapentin treats seizures and nerve pain but carries risks.
- Misuse rates for gabapentin prescriptions range from 40% to 65%.
- Combining gabapentin with depressants can be fatal.

Gabapentin, initially developed for seizures, has become a widely prescribed medication for various pain conditions, including neuropathic pain, diabetic neuropathy, and restless legs syndrome.
Its mechanism involves reducing nerve signaling, effectively calming abnormal nervous system activity. Beyond its FDA-approved uses for epilepsy and postherpetic neuralgia, gabapentin is frequently prescribed off-label for conditions like back pain, fibromyalgia, and agitation in dementia.
One of its key advantages is treating neuropathic pain, which often resists conventional painkillers. It also offers a safer alternative to opioids as it does not suppress breathing and is not metabolized by the liver.



