What is ARMR Sciences developing to combat fentanyl?

ARMR Sciences is developing a fentanyl vaccine designed to prevent overdose deaths by neutralizing the drug in the bloodstream.

How does the fentanyl vaccine work?

The vaccine prompts the body to create antibodies that bind to fentanyl, preventing it from reaching the brain and causing respiratory failure or death.

When will the fentanyl vaccine begin trials?

Clinical trials for the fentanyl vaccine are scheduled to begin early next year with 40 healthy adults in the Netherlands.

Home / Health / Fentanyl Vaccine: A New Shield Against Overdose?

Fentanyl Vaccine: A New Shield Against Overdose?

3 Dec, 2025

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Summary

A New York biotech firm is pioneering a fentanyl vaccine to prevent overdose deaths.
The vaccine aims to prevent fentanyl from reaching the brain by creating antibodies.
Trials on healthy adults are set to begin early next year in the Netherlands.

Fentanyl Vaccine: A New Shield Against Overdose?

A novel approach to combating the pervasive fentanyl crisis is emerging from a New York-based biotech company, ARMR Sciences. The company is developing a vaccine designed to prevent fentanyl overdoses by neutralizing the drug before it reaches the brain. This innovative vaccine functions by prompting the body to produce antibodies that bind to fentanyl, rendering it too large to cross the blood-brain barrier and avert fatal consequences.

Collin Gage, CEO of ARMR Sciences, explained that the vaccine conceptually acts like a suit of armor, offering a proactive solution rather than the reactive measures like Naloxone (Narcan) currently available. The development is based on research from the University of Houston and Tulane University, where rat trials demonstrated significant protection against fentanyl entering the brain, with potential for long-lasting immunity in humans.