Ex-NFLer Fights Brain Inflammation: Hope for Players

Casey Toohill, a former NFL defensive end, has retired and is now an advocate for players dealing with head injuries, describing his past career with 'existential dread' due to the physical toll.

He is now involved with the Concussion & CTE Foundation, partnering with Emory University School of Medicine on a clinical trial. This study will evaluate if baricitinib, an FDA-approved medication known for reducing inflammation, can alleviate depression and cognitive issues in former football players.

This research is critical as scientists aim to diagnose Chronic Traumatic Encephalopathy (CTE) in living individuals. CTE, a degenerative brain disease found in over 100 deceased former NFL players, has been linked to behavioral and emotional changes, including memory loss and mood swings.

The trial is recruiting men aged 30-55 with at least 11 years of tackle football experience, who are experiencing depression and cognitive concerns. Researchers emphasize they are not treating CTE directly but addressing potential underlying inflammation that may contribute to symptoms in at-risk individuals.

Christina Gavegnano, a lead investigator, explained that while acute inflammation aids healing, chronic inflammation can damage neurons. The hypothesis is that restoring normal inflammation levels could improve symptoms associated with various brain diseases, including CTE. Baricitinib is considered a promising candidate due to its established safety profile and once-daily dosage.

Toohill, who played for the Commanders, Eagles, and Bills, although not eligible for this specific trial due to his playing years, is actively encouraging former teammates to participate. He hopes such research provides much-needed hope and answers for players concerned about the long-term effects of head impacts.