Contraceptive Jab Linked to Rare Brain Tumors in Women

In August 2025, new research has revealed a concerning link between the Depo-Provera contraceptive jab and a heightened risk of developing meningioma, a rare and potentially deadly brain tumor. According to the studies, women who use the Depo-Provera jab for over a year are 3 to 5 times more likely to be diagnosed with a meningioma compared to those who do not use the injection.

The Depo-Provera jab, a hormone injection given every three months, is widely prescribed in the UK, with around 10,000 prescriptions issued monthly. However, many women using the jab remain unaware of the potential tumor risk. Meningiomas are slow-growing tumors that can cause a range of serious health issues, including vision loss, personality changes, memory loss, and even paralysis. While 70% of patients survive 10 years after diagnosis, between 10-20% die within 5 years.

Experts believe the synthetic hormone in the Depo-Provera jab, called progestogen, may bind to meningioma cells and contribute to their growth. The UK drug safety watchdog has now called on the manufacturer, Pfizer, to include a warning about the heightened meningioma risk in patient information leaflets. In the US, a class-action lawsuit is underway against Pfizer and other manufacturers, with over 500 women alleging the companies failed to adequately warn users of the risks.