What is chronic fatigue syndrome (CFS) according to Dr. Hector Bonilla?

Dr. Hector Bonilla describes CFS as a severe, incapacitating fatigue lasting over six months, interfering with daily activities and not improved by rest.

How many people in the United States have chronic fatigue syndrome?

As many as 3.3 million people in the United States struggle with chronic fatigue syndrome, though many remain undiagnosed.

What are the key symptoms of myalgic encephalomyelitis (ME)?

Key symptoms include severe fatigue, post-exertional malaise, dizziness, muscle and joint pain, poor sleep, and memory problems.

Home / Health / Beyond Tired: Unraveling Chronic Fatigue Syndrome

Beyond Tired: Unraveling Chronic Fatigue Syndrome

2 Dec, 2025

•

Summary

CFS causes incapacitating fatigue lasting over six months.
Post-exertional malaise is a hallmark symptom, causing energy crashes.
Causes are unknown, but infections like COVID-19 may trigger CFS.

Beyond Tired: Unraveling Chronic Fatigue Syndrome

Chronic Fatigue Syndrome (CFS), or myalgic encephalomyelitis (ME), is a complex, long-term illness marked by profound fatigue that significantly impacts daily life and does not improve with rest. Affecting millions, its defining characteristic is incapacitating exhaustion persisting for over six months, often leading to difficulties with concentration and basic tasks.

A significant hallmark of CFS is post-exertional malaise, where even minor physical or mental exertion triggers delayed, severe energy depletion and flu-like symptoms. Other common issues include dizziness, pain, sleep disturbances, and cognitive problems, with autonomic nervous system dysfunction also frequently observed.

The precise origins of CFS are still under investigation, but current research points to a combination of factors. Infections, genetic predisposition, and hormonal dysregulation are considered potential contributors, with a substantial percentage of patients reporting a preceding viral illness. While no cure exists, management strategies focus on symptom relief, pacing activities, and improving overall function.